‘Certainly, which is about suitable. I look for a Bodily understanding of biological units inside a bottom-up way. I do think you can distinguish 3 strains of research in my group at this time. The very first worries chromosome composition: how do you obtain a metre-very long DNA polymer folded and organised in this kind of microscopic cell? We now have formulated visualisation techniques that enable us to review how, such as, SMC proteins loop DNA (video on Youtube) as a way to Create up chromosomes.
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[Laughs] ‘It absolutely was unquestionably a great risk! At some time, I had been very well informed that it could go Mistaken and that I could grow to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Considering the fact that 2000, Dekker has shifted the main focus of his work towards biophysics where he studies the Attributes of one biomolecules and cells utilizing the equipment of nanotechnology. This variation of discipline was driven by his fascination for the outstanding functioning of Organic molecular buildings, and also with the prolonged-phrase perspective that numerous appealing discoveries might be anticipated Within this field.[five] Recent lines of research in his biophysics team are while in the areas of:[six]
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Our investigate ranges within the biophysics of DNA to artificial cells and outside of. You should take a look underneath with the spectrum of our recent projects.
Lots of similar developments adopted, where our group established different transistor variants like single-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into tiny proof-of-principle electronic circuits.
Example (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in gray, the rim in the pore is highlighted in pink, plus a 3D rendering from the movement of the DNA rod is shown.
The rotors harness Electrical power from the nanoscale h2o and ion stream which is generated by a static chemical or electrochemical probable gradient while in the nanopore, which can be established by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological ailments, suggesting approaches to developing Strength-transducing motors at nanoscale interfaces.
There was a single dilemma while — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule stage, conducting polymers were being basically not such fantastic conductors, which was fairly disappointing. We Hence broadened our look at to try to discover far more promising molecules.
Case in point (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is shown in gray, the rim on the pore is highlighted in crimson, along with a 3D rendering of the movement on the DNA rod is displayed.
Cees Dekker is Distinguished University Professor at TU Delft. Experienced like a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes from the nineties. Considering the fact that 2000, he moved to solitary-molecule biophysics and nanobiology. His current investigate focuses on (i) nanopores for protein sequencing; (ii) chromosome composition, particularly SMC motor protein; and (iii) ceesdekker developing a residing artificial cell from lifeless molecules. Dekker is really an elected member from the KNAW and fellow into the APS as well as the IOP.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever design in 2005. (nl)